05278202 is referenced by 218 patents and cites 6 patents.

A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.

Title
Biodegradable in-situ forming implants and methods of producing the same
Application Number
252645
Publication Number
5278202
Application Date
December 23, 1991
Publication Date
January 11, 1994
Inventor
David D Vanderbilt
Birmingham
AL, US
Donald R Cowsar
Birmingham
AL, US
James P English
Birmingham
AL, US
Richard L Dunn
Fort Collins
CO, US
Agent
Merchant Gould Smith Smith Edell & Welter
Assignee
Atrix Laboratories
CO, US
IPC
A61F 2/00
C08L 77/00
C08L 69/00
C08L 67/00
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