05277893 is referenced by 11 patents and cites 39 patents.

Proteins containing one or more disulfide bonds are radiolabeled with radionuclides of technetium or rhenium for use in diagnosis and treatment of a variety of pathologic conditions. Radiolabeling is accomplished by partial reduction of the disulfide bonds of the protein using Sn (II), or using other reducing agents followed by the addition of Sn (II), removal of excess reducing agent and reduction by-products, and addition of a specified amount of pertechnetate or perrhenate reducing agent, such as stannous tartrate, with the addition accomplished in such a manner that further reduction of the protein is limited. The resulting product may be stored frozen or lyophilized, with radiolabeling accomplished by the addition of pertechnetate or perrhenate solution.

Title
Direct radiolabeling of substrates containing monosulfides or disulfide bonds with radionuclides
Application Number
391474
Publication Number
5277893
Application Date
April 6, 1992
Publication Date
January 11, 1994
Inventor
Buck A Rhodes
Albuquerque
NM, US
Agent
Donovan F Duggan
Deborah A Peacock
Assignee
RhoMed Incorporated
NM, US
IPC
A61K 49/02
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