05270300 is referenced by 280 patents and cites 64 patents.

Methods and compositions are provided for the treatment and repair of defects in the cartilage or bone of humans and other animals as in full-thickness defects in joints. The defect in bone is filled with a matrix having pores large enough to allow cells to populate the matrix and to form blood vessels. The matrix filling the bone defect contains an angiogenic factor and also contains an osteogenic factor in an appropriate delivery system. To induce cartilage formation, a defect in cartilage is filled with a matrix having pores sufficiently large to allow cartilage repair cells to populate the matrix. The matrix filling the defect in cartilage contains a proliferation agent and also contains a transforming factor in an appropriate delivery system. The matrix may also contain a chemotactic agent to attract cartilage repair cells. In a full-thickness defect, the defect sites in bone and cartilage are separated from each other by a membrane, which is sealed to the cartilage-bone-junction and which prevents blood vessels and associated cells from penetrating from one site to the other.

Title
Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
Application Number
7/756164
Publication Number
5270300
Application Date
September 6, 1991
Publication Date
December 14, 1993
Inventor
Ernst B Hunziker
Riedholz
CH
Agent
Jane A Massaro
Edward F Mullowney
Assignee
Robert Francis Shaw
CA, US
IPC
A61K 37/36
A61K 37/24
A61K 37/22
C09H 3/02
C07K 15/06
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