05267985 is referenced by 172 patents and cites 18 patents.

The present invention provides a method and apparatus for enhancing the diffusion of a substance to a local area of material or tissue by providing ultrasonic energy to the substance and material in two or more distinct frequencies simultaneously. Each of the distinct frequencies of ultrasonic energy is chosen to enhance permeation of the substance through one or more diffusion rate-limiting sections of the material.

Title
Drug delivery by multiple frequency phonophoresis
Application Number
8/16796
Publication Number
5267985
Application Date
February 11, 1993
Publication Date
December 7, 1993
Inventor
James E Shapland
Shoreview, both
MN, US
Jin Shimada
Falcon Heights
MN, US
Agent
Merchant Gould Smith Edell Welter & Schmidt
Assignee
Trancell
MN, US
IPC
A61B 17/20
A61M 35/00
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