05266331 is referenced by 282 patents and cites 2 patents.

A solid controlled release, oral dosage form, the dosage form comprising a therapeutically effective amount of oxycodone or a salt thereof in a matrix wherein the dissolution rate in vitro of the dosage form, when measured by the USP Paddle Method of 100 rpm in 900 ml aqueous buffer (pH between 1.6 and 7.2) at 37.degree. C. is between 12.5% and 42.5% (by weight) oxycodone released after 1 hour, between 25% and 55% (by weight) oxycodone released after 2 hours, between 45% and 75% (by weight) oxycodone released after 4 hours and between 55% and 85% (by weight) oxycodone released after 6 hours, the in vitro release rate being independent of pH between pH 1.6 and 7.2 and chosen such that the peak plasma level of oxycodone obtained in vivo occurs between 2 and 4 hours after administration of the dosage form.

Title
Controlled release oxycodone compositions
Application Number
7/800549
Publication Number
5266331
Application Date
November 27, 1991
Publication Date
November 30, 1993
Inventor
Mark Chasin
Manalpan
NJ, US
John J Minogue
Mount Vernon
NY, US
Benjamin Oshlack
New York
NY, US
Agent
Steinberg & Raskin
Assignee
Euroceltique
LU
IPC
A61K 9/26
A61K 9/22
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