05235033 is referenced by 405 patents and cites 5 patents.

Alpha-morpholino subunits and polymer compositions composed of alpha-morpholino subunits are disclosed. These subunits can be linked together by uncharged linkages, one to three atoms in length, joining the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide. The polymers of the present invention can be used in place of standard RNA or DNA oligomers for a number of standard laboratory procedures, for example, as probes in solid-phase systems and nucleic acid hybridization analyses. Further, the polymers of the present invention have potential use as therapeutic agents in anti-sense-type technologies.

Title
Alpha-morpholino ribonucleoside derivatives and polymers thereof
Application Number
712396
Publication Number
5235033
Application Date
December 20, 1989
Publication Date
August 10, 1993
Inventor
Eugene P Stirchak
Corvallis
OR, US
Dwight D Weller
Corvallis
OR, US
James E Summerton
Corvallis
OR, US
Agent
Gary R Fabian
Peter J Dehlinger
Assignee
Anti Gene Development Group
OR, US
IPC
C07D 413/00
C08G 75/24
C08G 75/20
C08G 75/18
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