05225539 is referenced by 1065 patents and cites 6 patents.

An altered antibody is produced by replacing the complementarity determining regions (CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different specificity, using recombinant DNA techniques. The gene coding sequences for producing the altered antibody may be produced by site-directed mutagenesis using long oligonucleotides.

Title
Recombinant altered antibodies and methods of making altered antibodies
Application Number
903776
Publication Number
5225539
Application Date
October 25, 1991
Publication Date
July 6, 1993
Inventor
Gregory P Winter
Cambridge
GB
Agent
Spencer Frank & Schneider
Assignee
Medical Research Council
GB
IPC
C12N 15/13
C12N 5/12
A61K 39/395
C07K 15/28
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