05219548 is referenced by 36 patents and cites 8 patents.

Applicants describe the synthesis of fluorotamoxifen and iodotamoxifen analogs with the halogen atom positioned on the aliphatic chain of the tamoxifen molecule. The halogenated-tamoxifen derivatives possess superior binding affinities to estrogen receptors of pig uteri compared with tamoxifen. The fluorinated tamoxifens have potential use in imaging estrogen receptors by PET whereas the iodinated tamoxifens have potential use in imaging estrogen receptors by SPECT. Rapid and efficient methods of preparing fluorotamoxifen and iodotamoxifen derivatives with high specific activity are also disclosed. Fluorotamoxifen and iodotamoxifen derivatives may advantageously be used as anti-cancer therapeutic agents to halt estrogen-receptor positive tumors.

Title
High affinity halogenated-tamoxifen derivatives and uses thereof
Application Number
7/589928
Publication Number
5219548
Application Date
October 1, 1990
Publication Date
June 15, 1993
Inventor
Sidney Wallace
Houston
TX, US
David J Yang
Sugarland
TX, US
Agent
Arnold White Durkee
Assignee
Board of Regents The University of Texas System
TX, US
IPC
C07C 91/06
A61K 31/135
A61K 43/00
A61K 49/02
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