05215086 is referenced by 565 patents and cites 12 patents.

Method and apparatus for treating and controlling migraine by selectively applying a predetermined electrical signal to the patient's vagus nerve for stimulation thereof to alleviate the migraine attack. The signal is a pulse waveform having parameters programmed to desynchronize the patient's EEG if paroxysmal activity is detected in the EEG, or to synchronize the EEG if low voltage fast wave activity is detected. Alternatively, the application of the stimulating signal to the vagus nerve may be initiated manually by the patient upon recognition of the onset of a migraine attack. The neurostimulator device implanted in the patient to generate the appropriate signal has a power down circuit to conserve battery power between migraine episodes.

Title
Therapeutic treatment of migraine symptoms by stimulation
Application Number
7/695216
Publication Number
5215086
Application Date
May 3, 1991
Publication Date
June 1, 1993
Inventor
Ross G Baker Jr
Houston
TX, US
Joachim F Wernicke
League City
TX, US
Reese S Terry Jr
Houston
TX, US
Agent
Leitner Greene & Christensen
Assignee
Cyberonics
TX, US
IPC
A61N 1/36
View Original Source