05214134 is referenced by 250 patents and cites 2 patents.

A method of linking nucleosides with a siloxane bridge comprising reacting a 3'-silylated-5'-protected nucleoside with an unprotected nucleoside is disclosed. The silylated and unprotected nucleosides may be either monomeric nucleosides or the terminal nucleosides of an oligonucleotide or oligonucleotide analog. A method of synthesizing an oligonucleotide analog having siloxane internucleoside linkages is also disclosed. The method of synthesis comprises silylating a 5'-protected nucleoside with a bifunctional silylating reagent to form a 3'-silylated nucleoside, reacting the silylated nucleoside with an unprotected nucleoside in the presence of a base catalyst and repeating these steps to form an oligonucleotide analog. A modified solid phase synthesis method for preparing an oligonucleotide analog having siloxane internucleoside linkages is also disclosed.

Title
Process of linking nucleosides with a siloxane bridge
Application Number
7/581502
Publication Number
5214134
Application Date
September 12, 1990
Publication Date
May 25, 1993
Inventor
Frederick H Hausheer
San Antonio
TX, US
Ashis K Saha
Frazer
PA, US
Alexander L Weis
Berwyn
PA, US
Agent
Irving Newman
Assignee
Sterling Winthrop
NY, US
IPC
C07H 21/04
C07H 19/073
C07H 19/173
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