05213098 is referenced by 320 patents and cites 28 patents.

A post-extrasystolic potentiation (PESP) cardiac pacing energy stimulator for applying paired and/or triggered pacing stimulation pulses to the right atrium and/or ventricle incorporating one or more sensors, such as a venous oxygen saturation, ventricular, atrial, or arterial blood pressure, or intracardiac or systemic blood flow sensor, and signal processing circuitry for controlling the frequency of or number of heart cycles between periodic delivery of triggered or paired pacing to induce PESP for the treatment of congestive heart failure or other cardiac dysfunctions. Preferably, a first sensor, e.g., a ventricular or arterial blood pressure or flow sensor, is employed to monitor the performance of the heart, and develop a cardiac performance index (CPI) and a second sensor, e.g., an oxygen saturation sensor positioned in the coronary sinus, is employed to monitor cardiac muscle stress and develop a cardiac stress index (CSI) to balance performance and stress. The PESP stimulator may be incorporated into a dual chamber (DDD) pacing system with or without physiologic rate control and with or without backup cardioversion/defibrillation therapy capabilities or in a separate, single purpose device. The PESP stimulator has particular application in atrial stimulation for augmenting filling of the ventricles.

Title
Post-extrasystolic potentiation stimulation with physiologic sensor feedback
Application Number
7/736198
Publication Number
5213098
Application Date
July 26, 1991
Publication Date
May 25, 1993
Inventor
Paul M Stein
Maple Grove
MN, US
Russell L Lundstrom Jr
Minneapolis
MN, US
Tom D Bennett
Shoreview
MN, US
Agent
Harold R Patton
Dwight N Holmbo
Assignee
Medtronic
MN, US
IPC
A61N 1/365
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