05206023 is referenced by 358 patents and cites 38 patents.

Methods and compositions are provided for the treatment and repair of defects or lesions in the cartilage of humans and other animals. The defect or lesion in the cartilage may be first treated with an enzyme to remove proteoglycans from the defect area. To induce cartilage formation, the defect is filled or otherwise dressed with a biodegradable matrix having pores sufficiently large to allow repair cells to populate the matrix. The matrix filling the defect contains a proliferation agent at a concentration sufficient to stimulate proliferation of repair cells and a transforming factor in an appropriate delivery system to release the transforming factor at a concentration sufficient to transform repair cells in the matrix and defect area into cartilage-producing chondrocytes. The matrix may also contain a chemotactic agent to attract repair cells. The entire treatment may be carried out in a single arthroscopic or open surgical procedure.

Title
Method and compositions for the treatment and repair of defects or lesions in cartilage
Application Number
7/648274
Publication Number
5206023
Application Date
January 31, 1991
Publication Date
April 27, 1993
Inventor
Ernst B Hunziker
Riedholz
CH
Agent
Jane A Massaro
James F Haley Jr
Assignee
Robert F Shaw
CA, US
IPC
C09H 3/02
C07K 15/06
A61K 37/22
A61F 2/02
View Original Source