05204244 is referenced by 132 patents.

A process for producing chimeric antibodies using novel recombinant DNA vectors and homologous recombination in vivo is described. The recombinant DNA constructs of the invention can be used to transfect antibody producing cells so that targeted homologous recombination occurs in the transfected cells leading to gene modification and the production of chimeric antibody molecules by the transfected cells.

Title
Production of chimeric antibodies by homologous recombination
Application Number
113800
Publication Number
5204244
Application Date
September 14, 1988
Publication Date
April 20, 1993
Inventor
Kim R Folger Bruce
Seattle
WA, US
H Perry Fell
Redmond
WA, US
Agent
Pennie & Edmonds
Assignee
Oncogen
WA, US
IPC
C12N 5/00
C12N 15/00
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