05199428 is referenced by 764 patents and cites 2 patents.

A method and apparatus for stimulating the right and/or left carotid sinus nerves or the right stellate ganglion or the epidural space at about T.sub.2 with continuous and/or phasic electrical pulses in response to detected myocardial ischemia to decrease cardiac workload as a method to protect the myocardium. The automatic detection of the need for such stimulation is responsive to a change in ST segment variation different from a predetermined or programmed threshold suggesting acute myocardial ischemia and/or other criteria or indicators of myocardial ischemia, including changes if pH and/or oxygen saturation (SO.sub.2) detected from a sensor located in the heart, preferably the coronary sinus. The system is implemented with a dual chamber pacemaker with programming and telemetry capabilities for automatically recording in memory the aforementioned values for periods of time preceding and following each instance of stimulation for telemetry out on command and for programming "on" one or more of the sensors.

Title
Implantable electrical nerve stimulator/pacemaker with ischemia for decreasing cardiac workload
Application Number
7/673883
Publication Number
5199428
Application Date
March 22, 1991
Publication Date
April 6, 1993
Inventor
Ivan Bourgeois
Verviers
BE
Israel W P Obel
Johannesburg
ZA
Agent
Harold R Patton
John A Rissman
Assignee
Medtronic
MN, US
IPC
A61N 1/08
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