05198367 is referenced by 258 patents and cites 4 patents.

A method is described for measuring the amount of analyte present in a sample containing the analyte using a homogeneous amperometric immunoassay. The analyte is covalently bonded to a suitable carrier molecule, which is also covalently bonded to an electroactive molecule. The electroactive molecule, such as ferrocene carboxylic acid, contains a redox center which is capable of transferring a charge to an electrode. A preferred carrier molecule is bovine serum albumin (BSA), while suitable analytes include digoxin, theophylline and HCG. The immunoassay is conveniently performed by applying a voltage to a set of electrodes.

Title
Homogeneous amperometric immunoassay
Application Number
7/364731
Publication Number
5198367
Application Date
June 9, 1989
Publication Date
March 30, 1993
Inventor
Laura S Uretsky
9-1 Shadowbrook La., Milford, 01757
MA, US
Miki Hidaka
2040 Pelham Ave., Los Angeles, 90025
CA, US
Brenda D Manning
158 Canton St., North Easton, 02356
MA, US
Masuo Aizawa
2-19-4 Amanuma, Suginami-ku, Tokyo 167
JP
Agent
Arthur S Morgenstern
Nicholas I Slepchuk Jr
IPC
G01N 33/543
G01N 33/536
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