05192553 is referenced by 196 patents and cites 12 patents.

The present invention relates to hematopoietic stem and progenitor cells of neonatal or fetal blood that are cryopreserved, and the therapeutic uses of such stem and progenitor cells upon thawing. In particular, the present invention relates to the therapeutic use of fetal or neonatal stem cells for hematopoietic (or immune) reconstitution. Hematopoietic reconstitution with the cells of the invention can be valuable in the treatment or prevention of various diseases and disorders such as anemias, malignancies, autoimmune disorders, and various immune dysfunctions and deficiencies. In another embodiment, fetal or neonatal hematopoietic stem and progenitor cells which contain a heterologous gene sequence can be used for hematopoietic reconstitution in gene therapy. In a preferred embodiment of he invention, neonatal or fetal blood cells that have been cryopreserved and thawed can be used for utologous (self) reconstitution.

Title
Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
Application Number
119746
Publication Number
5192553
Application Date
November 10, 1988
Publication Date
March 9, 1993
Inventor
Gordon W Douglas
New York
NY, US
Hal E Broxmeyer
Indianapolis
IN, US
Edward A Boyse
Tucson
AZ, US
Assignee
Biocyte Corporation
NY, US
IPC
A61K 35/14
A61K 35/50
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