05175384 is referenced by 151 patents.

Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the T lymphocyte which is depleted. The transgene comprises a DNA sequence encoding a T cell receptor polypeptide variant which inhibits maturation of the T lymphocyte.

Title
Transgenic mice depleted in mature T-cells and methods for making transgenic mice
Application Number
7/280218
Publication Number
5175384
Application Date
December 5, 1988
Publication Date
December 29, 1992
Inventor
Antonius J M Berns
Spaarndam
NL
Paulus J A Krimpenfort
Amsterdam
NL
Agent
Richard F Trecartin
Assignee
GenPharm International
CA, US
IPC
C12N 15/00
View Original Source