05175273 is referenced by 239 patents and cites 7 patents.

Pyridinone or pyrimidinone nucleoside bases containing fused aromatic polycyclic rings are provided. These polycyclic nucleosides are incorporated into oligonucleotides and hybridized to complementary nucleic acid. Fluorescence spectroscopy and thermal denaturation profiles provided evidence that the polycyclic base is intercalated into the resulting duplex. The fused polycyclic ring systems optionally are substituted with reactive species which inactivate complementary nucleic acids. The oligonucleotides of this invention are useful as improved probes, diagnostic reagents, or for cleaving or derivatizing predetermined domains within nucleic acids.

Title
Nucleic acid intercalating agents
Application Number
7/213957
Publication Number
5175273
Application Date
July 1, 1988
Publication Date
December 29, 1992
Inventor
Mark D Matteucci
Burlingame
CA, US
Norbert W Bischofberger
San Carlos
CA, US
Agent
Max D Hensley
Daryl B Winter
Assignee
Genentech
CA, US
IPC
C07H 15/18
C07H 21/04
C07H 19/073
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