05174962 is referenced by 84 patents and cites 5 patents.

This invention relates to the apparatus, for sequencing natural or recombinant DNA and other polynucleotides. In particular, this invention relates to a method for sequencing polynucleotides based on mass spectrometry to determine which of the four bases (adenine, guanine, cytosine or thymine) is a component of the terminal nucleotide. In particular, the present invention relates to identifying the individual nucleotides by the mass of stable nuclide markers contained within either the dideoxynucleotides, the DNA primer, or the deoxynucleotide added to the primer. This invention is particularly useful in identifying specific DNA sequences in very small quantities in biological products produced by fermentation or other genetic engineering techniques. The invention is therefore useful in evaluating safety and other health concerns related to the presence of DNA in products resulting from genetic engineering techniques.

Title
Apparatus for determining DNA sequences by mass spectrometry
Application Number
209247
Publication Number
5174962
Application Date
January 24, 1990
Publication Date
December 29, 1992
Inventor
Thomas M Brennan
Hillsboro
CA, US
Agent
Allegretti & Witcoff
Assignee
Genomyx
CA, US
IPC
G01N 30/02
G01N 31/12
G01N 23/06
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