05173747 is referenced by 86 patents and cites 4 patents.

In apparatus useful in immunoassay of a fluid, light is directed to an optical sensor wherein the light is transmitted to a replaceable optical device that is responsive to index of refraction in a sensing region thereof that is exposed to the fluid. One portion of the light is transmitted via a reference path to a first detector. Another portion of the light is transmitted via a sensing path that includes the sensing region to another detector. A ratioing device receives an output from each detector and provides a signal responsive to the ratio of the outputs. The replaceable optical device typically comprises a pair of channel waveguides in directional coupling arrangement, or a pair of channel waveguides in an interferometer arrangement, or a ridge waveguide having a serpentine path.

Title
Integrated optical directional-coupling refractometer apparatus
Application Number
7/585438
Publication Number
5173747
Application Date
September 20, 1990
Publication Date
December 22, 1992
Inventor
Richard W Ridgway
Westerville
OH, US
Anthony A Boiarski
Columbus
OH, US
Agent
Klaus H Wiesmann
Philip M Dunson
Assignee
Battelle Memorial Institute
OH, US
IPC
G01B 9/02
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