05171249 is referenced by 554 patents and cites 56 patents.

An endoscopic clip applying system as described which contains a venting system and a clip applying support system which prevents closure of the mechanism before firing. Also, the system ensures proper loading of the clips and prevents them from falling out during loading. Further, the system describes an easily manufacturable, positively opening system which has minimized size requirements. Furthermore, a lock-out mechanism is provided so that the mechanism may not be inadvertently fired. The shaft resists excessive torque as well as holds the clip in place during firing. There are provisions for sealant and non back-up of the clips, as well as features which make the clip properly placed for closure.

Title
Endoscopic multiple ligating clip applier
Application Number
7/680215
Publication Number
5171249
Application Date
April 4, 1991
Publication Date
December 15, 1992
Inventor
John E Burbank
Ridgefield
CT, US
Michael A Murray
Bellevue
KY, US
Rudolph H Nobis
Cincinnati
OH, US
Jerome E Reckelhoff
Cincinnati
OH, US
David Stefanchik
Mason
OH, US
Agent
Paul A Coletti
Assignee
Ethicon
NJ, US
IPC
A61B 17/00
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