05169933 is referenced by 186 patents and cites 5 patents.

Covalently-linked complexes (CLCs) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable of promoting CLC-target cell interaction are disclosed. Methods for using the claimed CLCs to obtain enhanced in vivo cytotoxicity and enhanced in vivo imaging are also described.

Title
Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
Application Number
232337
Publication Number
5169933
Application Date
August 7, 1989
Publication Date
December 8, 1992
Inventor
Everett J Nichols
Seattle
WA, US
Alan R Fritzberg
Edmonds
WA, US
Paul G Abrams
Seattle
WA, US
A Charles Morgan Jr
Edmonds
WA, US
David C Anderson
Seattle
WA, US
Assignee
NeoRx Corporation
WA, US
IPC
A61K 49/02
C07K 7/38
C07K 7/36
C07K 7/34
C07K 7/10
C07K 7/08
C07K 7/06
C07K 17/02
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