05169637 is referenced by 71 patents and cites 1 patents.

A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for identifying the same. SPLVs are characterized by lipid bilayers enclosing aqueous compartments containing one or more entrapped solutes, the concentration of such solutes in each aqueous compartment being substantially equal to the emunization of solutes used to prepare the SPLVs. The bilayers of SPLVs are substantially non-compressed. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.

Title
Stable plurilamellar vesicles
Application Number
521176
Publication Number
5169637
Application Date
April 2, 1991
Publication Date
December 8, 1992
Inventor
Sol M Gruner
Lawrenceville
NJ, US
Marc J Ostro
Griggstown
NJ, US
Richard S Ginsberg
Monroe Township, Salem County
NJ, US
Steven J Weiss
Hightstown
NJ, US
Mircea C Popescu
Plainsboro
NJ, US
Andrew S Janoff
Yardley
PA, US
Michael W Fountain
Griggstown
NJ, US
Robert P Lenk
Lambertville
NJ, US
Agent
Ronald G Ort
Allen Bloom
Assignee
The Liposome Company
NJ, US
IPC
A61K 31/43
A61K 31/65
A61K 31/70
A61K 37/00
A61K 37/22
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