05165407 is referenced by 1001 patents and cites 10 patents.

Implantable enzymatic sensors (25, 43, 44) for biochemicals such as glucose are provided having an ideal size and geometry for optional long term implantation and linear responses over the concentration ranges of interest. The sensors (25, 43, 44) include an elongated body (10, 26, 46) supporting an indicating electrode section having an appropriate enzyme immobilized thereon to present an enzymatic indicating surface (21, 33, 54). A permeable synthetic polymer membrane (24, 42, 56) is applied over the sensor body (10, 26, 46) to protect the enzyme and regulate diffusion of analyte therethrough, to ensure linearity of sensor response. The sensors (25, 43) are of flexible design and can be implanted using a catheter. Alternately, the sensor (44) includes an internal indicating electrode body (46) housed within an apertured, hollow needle (48). A holder (66) affixed to the needle (48) allows for easy manipulation and implantation of the sensor (44).

Title
Implantable glucose sensor
Application Number
511049
Publication Number
5165407
Application Date
April 9, 1991
Publication Date
November 24, 1992
Inventor
Yanan Zhang
Lawrence
KS, US
Gerard Reach
Paris Cedex
FR
Robert Sternberg
Thiais
FR
Daniel R Thevenot
Paris Cedex
FR
Brian S Hill
Lawrence
KS, US
Dilbir S Bindra
Lawrence
KS, US
George S Wilson
Lawrence
KS, US
Agent
Hovey Williams Timmons & Collins
Assignee
The University of Kansas
KS, US
IPC
A61B 5/00
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