05153265 is referenced by 92 patents and cites 2 patents.

A biologically active CSF-1 protein is selectively conjugated via certain amino acid residues or carbohydrate moieties to a water-soluble polymer selected from polyethylene glycol or polypropylene glycol homopolymers, polyoxyethylated polyols, or polyvinyl alcohol. The resulting conjugated CSF-1 is biologically active and has increased circulating half-life in mammals, compared to that of the unconjugated protein. The conjugated CSF-1 may be used to stimulate the immune response or to provide more cells to be stimulated.

Title
Conjugation of polymer to colony stimulating factor-1
Application Number
146275
Publication Number
5153265
Application Date
August 30, 1990
Publication Date
October 6, 1992
Inventor
John D Young
Walnut Creek
CA, US
Danute E Nitecki
Berkeley
CA, US
Lois Aldwin
San Mateo
CA, US
Walter J Laird
Pinole
CA, US
Nandini Katre
El Cerrito
CA, US
Margaret Moreland
Berkeley
CA, US
Kirston E Koths
El Cerrito
CA, US
Paula J Shadle
Belmont
CA, US
Agent
Albert P Halluin
Jane R McLaughlin
Philip L McGarrigle
Assignee
Cetus Corporation
CA, US
IPC
A61K 37/02
C07G 7/00
C08L 89/00
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