05149794 is referenced by 125 patents.

This invention relates to a novel method of drug targeting which comprises covalently binding a drug to a lipid carrier. This composition has the unique ability to both enhance the rate at which an antineoplastic or antiviral drug crosses the plasma membrane, and to direct the drug within the cell to specific organelles. The versatility of these conjugates may be further enhanced by including a spacer group between the drug and the lipid which may act to modulate drug release at the target site.

Title
Covalent lipid-drug conjugates for drug targeting
Application Number
7/607982
Publication Number
5149794
Application Date
November 1, 1990
Publication Date
September 22, 1992
Inventor
John F Witte
Portland
OR, US
Michael H B Stowell
Salt Lake City
UT, US
Ronald W McClard
Portland
OR, US
David W Parks
Seattle
WA, US
Milton B Yatvin
Portland
OR, US
Agent
Allegretti & Witcoff
Assignee
State of Oregon
OR, US
IPC
A61K 31/70
A61K 37/22
C07H 17/00
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