05143854 is referenced by 1328 patents and cites 55 patents.

Polypeptide arrays can be synthesized on a substrate by attaching photoremovable groups to the surface of a substrate, exposing selected regions of the substrate to light to activate those regions, attaching an amino acid monomer with a photoremovable group to the activated regions, and repeating the steps of activation and attachment until polypeptides of the desired length and sequences are synthesized. The resulting array can be used to determine which peptides on the array can bind to a receptor.

Title
Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
Application Number
362901
Publication Number
5143854
Application Date
March 7, 1990
Publication Date
September 1, 1992
Inventor
Lubert Stryer
Stanford
CA, US
Stephen P A Fodor
Palo Alto
CA, US
J Leighton Read
Palo Alto
CA, US
Michael C Pirrung
Durham
NC, US
Agent
Vern Norviel
Kevin R Kaster
Kenneth J Nussbacher
Assignee
Affymax Technologies
AN
IPC
B01J 19/00
C07K 1/04
G01N 33/543
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