05122614 is referenced by 375 patents and cites 3 patents.

Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted onto the polypeptide backbone by means of stable, hydrolysis-resistant urethane (carbamate) linkages.

Title
Active carbonates of polyalkylene oxides for modification of polypeptides
Application Number
340928
Publication Number
5122614
Application Date
April 19, 1990
Publication Date
June 16, 1992
Inventor
Shmuel Zalipsky
Edison
NJ, US
Agent
Craig J Arnold
John P White
Assignee
Enzon
NJ, US
IPC
C07D 211/94
C07D 207/46
View Original Source