A mouth-to-mouth barrier for facilitating mouth-to-mouth resuscitation of a heart attack or accident victim or the like while protecting a rescuer, includes a transparent shield and a breathing tube extending through an opening in the shield. A light weight air impermeable plate is positioned within the breathing tube and is free to move between a lower position which permits air to flow from the rescuer around the plate and through the tube and an upper position which blocks airflow from the victim back towards the rescuer. The breathing tube has a plurality of longitudinally extending strengthening ribs and an integrally molded grid on the bottom thereof to strengthen and rigidize the structure. The plate is a different color than the breathing tube to enhance the perception of safety by a potential rescuer. Alphanumeric information, including precautionary notes and instructions are printed on the transparent shield.