05112596 is referenced by 76 patents and cites 1 patents.

The permeability of the blood-brain barrier to endogenous or exogenous neuropharmaceutical or diagnostic agents in an individual's blood stream is increased by administering a bradykinin agonist of blood-brain barrier permeability, such as N-acetyl [Phe.sup.8 (CH.sub.2 -NH)Arg.sup.9 ] bradykinin, to the individual. The bradykinin agonist of blood-brain barrier permeability is co-administered with the agent of interest into a blood vessel such as a vein. This co-administration allows the agent of interest to pass the blood-brain barrier into the brain compartment.

Title
Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
Application Number
7/512913
Publication Number
5112596
Application Date
April 23, 1990
Publication Date
May 12, 1992
Inventor
Bernard Malfroy Camine
Arlington
MA, US
Agent
Hamilton Brook Smith & Reynolds
Assignee
Alkermes
MA, US
IPC
A61K 37/00
G01N 1/00
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