05112455 is referenced by 217 patents and cites 15 patents.

A method of determining the concentration of a preselected analyte species present in a sample fluid is disclosed, which method comprises: (a) providing an external computational means, a reference electrode and at least one substantially dry-stored sensor capable of exhibiting a response to changes in the concentration of a preselected analyte species before the sensor attains full equilibrated wet-up; (b) establishing electrical contact between the sensor, reference electrode and external computational means; (c) contacting the sensor and reference electrode with a calibrant fluid; (d) performing a first signal measurement in a first time window in the presence of the calibrant fluid; (e) displacing the calibrant fluid after performing the first signal measurement; (f) contacting the sensor and reference electrode with a sample fluid; (g) performing a second signal measurement in a second time window in the presence of the sample fluid; and (h) relating the first and second signal measurements to determine the concentration of the preselected analyte species in the sample fluid before said sensor attains full equilibrated wet-up. Alternative methods are disclosed further for collecting, relating and manipulating the results of the signal measurements to provide useful estimates of the analyte concentrations of interest.

Title
Method for analytically utilizing microfabricated sensors during wet-up
Application Number
7/555976
Publication Number
5112455
Application Date
July 20, 1990
Publication Date
May 12, 1992
Inventor
Michael P Zelin
Plainsboro
NJ, US
Henry J Wieck
Plainsboro
NJ, US
Jody A Tirinato
Plainsboro
NJ, US
Nicolaas J Smit
Woodlawn
CA
Sylvia Piznik
Jackson
NJ, US
Imants R Lauks
Yardley
PA, US
Lisa A Holleritter
Oak Ridge
NJ, US
Graham Davis
Plainsboro
NJ, US
Stephen N Cozzette
Highstown
NJ, US
Agent
Pennie & Edmonds
Assignee
I Stat Corporation
NJ, US
IPC
C25F 7/00
G01N 27/26
View Original Source