05107065 is referenced by 318 patents and cites 10 patents.

Regulation of expression of genes encoded for in plant cell genomes is achieved by integration of a gene under the transcriptional control of a promoter which is functional in the host and in which the transcribed strand of DNA is complementary to the strand of DNA that is transcribed from the endogenous gene(s) one wishes to regulate. The integrated gene, referred to as anti-sense, provides an RNA sequence capable of binding to naturally existing RNAs, exemplified by polygalacturonase, and inhibiting their expression, where the anti-sense sequence may bind to the coding, non-coding, or both, portions of the RNA. The antisense construction may be introduced into the plant cells in a variety of ways and be integrated into the plant genome for inducible or constitutive transcription of the anti-sense sequence. A wide variety of plant cell properties may be modifed by employing this technique.

The pCGN978xK12 was deposited at the A.T.C.C. on Mar. 25, 1986, and given Accession No. 67064 and pCGN1401 was deposited on Oct. 7, 1986 at the A.T.C.C. and given Accession No. 67227.

Title
Anti-sense regulation of gene expression in plant cells
Application Number
845676
Publication Number
5107065
Application Date
August 30, 1988
Publication Date
April 21, 1992
Inventor
Vic Knauf
Davis
CA, US
William R Hiatt
Davis
CA, US
Jean C Kridl
Davis
CA, US
Christine K Shewmaker
Davis
CA, US
Agent
Bertram I Rowland
Barbara Rae Venter
Assignee
Calgene
CA, US
IPC
C07H 15/12
C12N 5/00
C12N 15/00
A01H 1/04
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