05089261 is referenced by 89 patents and cites 8 patents.

The present invention is a process for preparing a pharmaceutical composition comprising a biologically active conjugated protein. It comprises a polyethylene glycol or a polyoxyethylated polyol conjugated to IL-2. This protein is conjugated to reduce its immunogenicity, and increase its solubility, and increase its circulating in vivo half-life.

Title
Preparation of a polymer/interleukin-2 conjugate
Application Number
299235
Publication Number
5089261
Application Date
September 29, 1989
Publication Date
February 18, 1992
Inventor
Lois Aldwin
San Mateo
CA, US
Robert J Goodson
Albany
CA, US
Nandini Katre
El Cerrito
CA, US
Danute E Nitecki
Berkeley
CA, US
Agent
Philip L McGarrigle
Assignee
Cetus Corporation
CA, US
IPC
C07K 17/00
A61K 45/05
A61K 31/745
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