05075078 is referenced by 182 patents and cites 23 patents.

Improved chromatographic strip binding assay devices are provided for determining the presence or amount of an analyte present in a patient sample. Assay label reagents interact with capture reagents immobilized in a testing region on the strip substrate to generate a visually detectable image indicative of the test result. The test result images include a minus sign (-) to indicate a negative test result for analyte which image is generated if the suspect analyte is absent in the patient sample and a plus sign (+) to indicate a positive test result for analyte which image is generated if the suspect analyte is present or is present at a pre-determined concentration in the patient sample. The immobilized capture reagents responsible for the location and configuration of the test result images are applied to the strip at an angled orientation with respect to the fluid flow direction of the strip to ensure that sharp substantially complete test result images are formed during performance of the assay. The devices provide substantially self-performing assays having inherently clear test results which are not subject to misinterpretation by the skilled or untrained user.

Title
Self-performing immunochromatographic device
Application Number
7/417346
Publication Number
5075078
Application Date
October 5, 1989
Publication Date
December 24, 1991
Inventor
Frank Walsworth
Gurnee
IL, US
Russell B Richerson
Lake Zurich
IL, US
Paul Brookhart
Gurnee
IL, US
Michael Beggs
Waukegan
IL, US
Eugene W Osikowicz
Lake Zurich
IL, US
Agent
Daniel R Curry
Assignee
Abbott Laboratories
IL, US
IPC
G01N 21/77
G01N 30/90
G01N 31/22
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