A surgical instrument is disclosed for ablation of organs or parts of organs or for generally cutting and applying surgical clips to the organ or body tissue. The instrument includes an elongated body having a pair of pincer jaws connected to the distal end, one jaw being fixed, and the other jaw being pivotally mounted at its proximal end for movement toward and away from the fixed jaw for gripping body tissue therebetween. A camming tube is provided for retaining the jaws in the closed position to firmly grip tissue. The instrument includes a knife for cutting the organ, and a tool which carries a cam for propelling suture clips into the tissue. The jaws, the knife and the suture clip application tool are all controllable from the proximal end by the surgeon to facilitate remote control when the instrument is inserted into a trocar or other guide tube.