05061492 is referenced by 155 patents and cites 19 patents.

A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of water-soluble drug.

Title
Prolonged release microcapsule of a water-soluble drug
Application Number
667096
Publication Number
5061492
Application Date
January 24, 1990
Publication Date
October 29, 1991
Inventor
Takatsuka Yashiki
Hyogo
JP
Yasuaki Ogawa
Osaka
JP
Hiroaki Okada
Osaka
JP
Agent
Wegner Cantor Mueller & Player
Assignee
Takeda Chemical
JP
IPC
A61F 2/00
B01J 13/12
A61K 9/52
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