05045538 is referenced by 43 patents and cites 5 patents.

A method for treating mammals suffering from skeletal muscle wasting and/or intracellular protein degradation of skeletal muscle systems by administering to the mammal an amount of tetracycline which results in a significant reduction of the muscle wasting and protein degradation is disclosed. In addition, there is also disclosed a method of increasing the protein content of skeletal muscle systems of mammals by administration of tetracyclines. The tetracyclines useful in the above methods are both antimicrobial and non-antimicrobial. In a preferred embodiment, the method of treatment utilizes a non-antimicrobial tetracycline such as dedimethylaminotetracycline (CMT).

Title
Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines
Application Number
7/545395
Publication Number
5045538
Application Date
June 28, 1990
Publication Date
September 3, 1991
Inventor
Nangavarum S Ramamurthy
Smithtown
NY, US
Thomas F McNamara
Port Jefferson
NY, US
Lorne M Golub
Smithtown
NY, US
Kenneth Gorray
Fresh Meadows
NY, US
Jonathan Maimon
Rego Park
NY, US
Robert A Greenwald
Melville
NY, US
Bruce Schneider
Great Neck
NY, US
Agent
Hoffmann & Baron
Assignee
The Research Foundation of State University of New York
NY, US
IPC
A61K 31/65
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