05041138 is referenced by 401 patents and cites 20 patents.

Methods and artificial matrices for the growth and implantation of cartilaginous structures and surfaces are disclosed. In the preferred embodiments, chondrocytes are grown on biodegradable, biocompatible fibrous polymeric matrices. Optionally, the cells are proliferated in vitro until an adequate cell volume and density has developed for the cells to survive and proliferate in vivo. One advantage of the matrices is that they can be cast or molded into a desired shape, on an individual basis, so that the final product closely resembles a patient's own ear or nose. Alternatively, flexible matrices can be used which can be manipulated at the time of implantation, as in a joint, followed by remodeling through cell growth and proliferation in vivo. The cultured cells can also be maintained on the matrix in a nutrient media for production of bioactive molecules such as angiogenesis inhibiting factor.

Title
Neomorphogenesis of cartilage in vivo from cell culture
Application Number
933018
Publication Number
5041138
Application Date
April 17, 1989
Publication Date
August 20, 1991
Inventor
Robert S Langer
Newton
MA, US
Charles A Vacanti
Lexington
MA, US
Joseph P Vacanti
Winchester
MA, US
Agent
Kilpatrick & Cody
Assignee
Children s Hospital
MA, US
Massachusetts Institute of Technology
MA, US
IPC
A61K 37/00
C07C 245/00
A61F 2/18
A61F 2/28
View Original Source