05023243 is referenced by 410 patents and cites 3 patents.

For use in controlling biologic functions in an organism, a stabilized oligonucleotide, preferably in a phosphotriester form, having a base sequence substantially complementary to a portion of messenger ribonucleic acid coding for a biological component, such as a protein, of the organism. The oligonucleotide has about fourteen bases or more, such as twenty-three bases, and can be a deoxyribonculeotide. The oligonucleotide sequence can be derived from the organism's ribonucleic or deoxyribonucleic acid that codes for a vital protein, and can be synthesized in bulk either chemically or by insertion into a plasmid.

Title
Oligonucleotide therapeutic agent and method of making same
Application Number
314124
Publication Number
5023243
Application Date
May 15, 1989
Publication Date
June 11, 1991
Inventor
Richard H Tullis
La Jolla
CA, US
Agent
Pretty Schroeder Brueggemann & Clark
Assignee
Molecular Biosystems
CA, US
IPC
A61K 48/00
A61K 31/725
C07H 21/04
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