05019400 is referenced by 302 patents and cites 27 patents.

A process for preparing microspheres using very cold temperatures to freeze polymer-biologically active agent mixtures into polymeric microspheres with very high retention of biological activity and material. Polymer is dissolved in a solvent together with an active agent that can be either dissolved in the solvent or dispersed in the solvent in the form of microparticles. The polymer/active agent mixture is atomized into a vessel containing a liquid non-solvent, alone or frozen and overlayed with a liquified gas, at a temperature below the freezing point of the polymer/active agent solution. The cold liquified gas or liquid immediately freezes the polymer droplets. As the droplets and non-solvent for the polymer is warmed, the solvent in the droplets thaws and is extracted into the non-solvent, resulting in hardened microspheres.

Title
Very low temperature casting of controlled release microspheres
Application Number
7/346143
Publication Number
5019400
Application Date
May 1, 1989
Publication Date
May 28, 1991
Inventor
Larry R Brown
Newton
MA, US
Michael S Healy
E. Bridgewater
MA, US
Wayne R Gombotz
Lexington
MA, US
Agent
Kilpatrick & Cody
Assignee
Enzytech
MA, US
IPC
B01J 13/02
C08K 7/16
B29B 9/00
A61K 9/58
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