05017566 is referenced by 42 patents and cites 63 patents.

Inclusion complexes of hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of .beta.- and .gamma.-cyclodextrin with the reduced, biooxidizable, blood-brain barrier penetrating, lipoidal forms of dihydropyridine.revreaction.pyridinium salt redox systems for brain-targeted drug delivery provide a means for stabilizing the redox systems, particularly against oxidation. The redox inclusion complexes also provide a means for decreasing initial drug concentrations in the lungs after administration of the systems, leading to decreased toxicity. In selected instances, complexation results in substantially improved water solubility of the redox systems as well.

Title
Redox systems for brain-targeted drug delivery
Application Number
174945
Publication Number
5017566
Application Date
November 3, 1989
Publication Date
May 21, 1991
Inventor
Nicholas S Bodor
Gainesville
FL, US
Agent
Mary Katherine Baumeister
Assignee
University of Florida
FL, US
IPC
C08B 37/16
A61K 31/735
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