05011472 is referenced by 209 patents and cites 23 patents.

Devices and methods are disclosed to provide hybrid, modular systems for the constitutive delivery of appropriate dosages of active factor to a subject and, in some instances, to specific anatomical regions of the subject. The systems include a cell reservoir containing living cells capable of secreting an active agent, which is preferably adapted for implantation within the body of the subject and further includes at least one semipermeable membrane, whereby the transplanted cells can be nourished by nutrients transported across the membrane while at the same time protected from immunological, bacterial, and viral assault. The systems further include a pumping means, which can be implantable or extracorporeal, for drawing a body fluid from the subject into the cell reservoir and for actively transporting the secreted biological factors from the cell reservoir to a selected region of the subject.

Title
Implantable delivery system for biological factors
Application Number
7/240939
Publication Number
5011472
Application Date
October 6, 1988
Publication Date
April 30, 1991
Inventor
Luigi Miracoli
Genoa
IT
George Panol
Warwick
RI, US
Pierre M Galletti
Providence
RI, US
Patrick Aebischer
Providence
RI, US
Agent
Thomas J Engellener
Assignee
Brown University Research Foundation
RI, US
IPC
A61M 31/00
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