05007790 is referenced by 167 patents and cites 15 patents.

Sustained-release oral drug-dosage forms that release drug in solution at a rate controlled by the solubility of the drug are described. The dosage form comprises a tablet or capsule which comprises a plurality of particles of a dispersion of a limited solubility drug in a hydrophilic, water-swellable, crosslinked polymer that maintains its physical integrity over the dosing lifetime but thereafter rapidly dissolves. Once ingested, the particles swell to promote gastric retention and permit the gastric fluid to penetrate the particles, dissolve drug and leach it from the particles, assuring that drug reaches the stomach in the solution state which is less injurious to the stomach than solid-state drug.

Title
Sustained-release oral drug dosage form
Application Number
7/336440
Publication Number
5007790
Application Date
April 11, 1989
Publication Date
April 16, 1991
Inventor
John W Shell
Hillsborough
CA, US
Agent
Irell & Manella
Assignee
DepoMed Systems
CA, US
IPC
A61K 9/48
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