05004681 is referenced by 199 patents and cites 7 patents.

The present invention relates to hematopoietic stem and progenitor cells of neonatal or fetal blood that are cryopreserved, and the therapeutic uses of such stem and progenitor cells upon thawing. In particular, the present invention relates to the therapeutic use of fetal or neonatal stem cells for hematopoietic (or immune) reconstitution. Hematopoietic reconstitution with the cells of the invention can be valuable in the treatment or prevention of various diseases and disorders such as anemias, malignancies, autoimmune disorders, and various immune dysfunctions and deficiencies. In another embodiment, fetal or neonatal hematopoietic stem and progenitor cells which contain a heterologous gene sequence can be used for hematopoietic reconstitution in gene therapy. In a preferred embodiment of the invention, neonatal or fetal blood cells that have been cryopreserved and thawed can be used for autologous (self) reconstitution.

Title
Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
Application Number
7/119746
Publication Number
5004681
Application Date
November 12, 1987
Publication Date
April 2, 1991
Inventor
Gordon W Douglas
New York
NY, US
Hal E Broxmeyer
Indianapolis
IN, US
Edward A Boyse
New York
NY, US
Agent
Pennie & Edmonds
Assignee
Biocyte Corporation
NY, US
IPC
A61K 35/14
A01N 1/02
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