04988617 is referenced by 330 patents and cites 2 patents.

Assay for determing the nucleic acid sequence in a region of a nucleic acid test substance having a known normal sequence and a known possible mutation at at least one target nucleotide position. Oligonucleotide probes are selected to anneal to immediately adjacent segments of a substantially complementary test DNA or RNA molecule. The target probe has an end region wherein one of the end region nucleotides is complementary to the normal or abnormal nucleotide at the corresponding target nucleotide position. A linking agent is added under conditions such that when the target nucleotide is correctly base paired, the probes are covalently joined and if not correctly base paired, the probes are incapable of being covalently joined under such conditions. The presence or absence of linking is detected as an indication of the sequence of the target nucleotide.

Title
Method of detecting a nucleotide change in nucleic acids
Application Number
7/173280
Publication Number
4988617
Application Date
March 25, 1988
Publication Date
January 29, 1991
Inventor
Leroy Hood
Pasadena
CA, US
Ulf Landegren
Pasadena
CA, US
Agent
Flehr Hohbach Test Albritton & Herbert
Assignee
California Institute of Technology
CA, US
IPC
C12N 15/00
C07H 15/12
C12Q 1/00
C12Q 1/68
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