An adaptive data acquisition multiplexing system having a monitor terminal and one or more remote terminals with a communication link between them. The remote terminals each include signal conditioning for a plurality of sensors. Upon commands from the monitor terminal, signals providing the remote terminals' current configuration and status, and instructions for changing the remote terminal configuration, are transmitted from each remote terminal to the monitor terminal. Menu driven prompts at the monitor terminal permit commands to be transmitted from the monitor terminal to the remote terminals, selectively altering the configuration of any remote terminal to enable it to acquire and transmit data, as well as its configuration and status information, in the desired format. Alterations in any remote terminal's configuration can then be verified at the monitor terminal.