04973493 is referenced by 316 patents and cites 27 patents.

A method for modifying the solid surface to improve its biocompatibility is disclosed. The method employs molecules of a biocompatible agent and a chemical linking moiety possessing a photochemically reactive group capable upon activation of covalently bonding to the solid surface and possessing a different reactive group as capable upon activation of covalently bonding to separate molecules of the biocompatible agent. The method comprises applying stimulus to sequentially activate the groups and covalently bind the different reactive group of the linking moiety to the molecules of the biocompatible agent and to photochemically covalently bind the linking moiety to the solid surface with a sufficient population density to enable the molecules of the biocompatible agent to effectively shield the solid surface and to provide a biocompatible surface.

Title
Method of improving the biocompatibility of solid surfaces
Application Number
920567
Publication Number
4973493
Application Date
October 15, 1987
Publication Date
November 27, 1990
Inventor
Patrick E Guire
Eden Prairie
MN, US
Agent
Gregory P Kaihoi
James R Bauman Mary P Haller
Assignee
Bio Metric Systems
MN, US
IPC
A61F 2/54
A61K 1/02
A01N 1/02
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