04960790 is referenced by 232 patents and cites 2 patents.

Derivatives of taxol represented by the formula ##STR1## wherein R and R' are each H or the residue of an amino acid selected from the group consisting of alanine, leucine, isoleucine, saline, phenylalanine, proline, lysine and arginine or a group of the formula ##STR2## wherein n is an integer of 1 to 3 and R.sup.2 and R.sup.3 are each hydrogen on an alkyl radical having from one to three carbon atoms or wherein R.sup.2 and R.sup.3 together with the nitrogen atom to which they are attached form a saturated heterocyclic ring having four to five carbon atoms, with the proviso that at least one of R and R.sup.1 is not hydrogen, are provided together with pharmaceutical compositions of such derivatives. The taxol derivatives have increased water solubility as compared to taxol, and have excellent antitumor activity.

Title
Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
Application Number
7/321152
Publication Number
4960790
Application Date
March 9, 1989
Publication Date
October 2, 1990
Inventor
Abraham E Mathew
Lenexa
KS, US
Valentino J Stella
Lawrence
KS, US
Agent
Birch Stewart Kolasch & Birch
Assignee
University of Kansas
KS, US
IPC
C07D 305/14
A61K 31/335
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