04954487 is referenced by 128 patents and cites 18 patents.

A large group of lipophilic, pharmacologically active compounds can be effectively delivered across intact skin by applying them topically in a binary, penetration-enhancing vehicle containing (1) a C.sub.3 -C.sub.4 diol, diol ester, or diol ether and (2) a cell envelope-disordering compound. This vehicle provides surprising enhancement of skin penetration for the pharmacological active, compared to either component alone.

Title
Penetrating topical pharmaceutical compositions
Application Number
1974
Publication Number
4954487
Application Date
February 15, 1989
Publication Date
September 4, 1990
Inventor
Richard R Wickett
Ross
OH, US
Maurice E Loomans
Cincinnati
OH, US
Eugene R Cooper
Cincinnati
OH, US
Agent
Steven J Goldstein
George W Allen
Milton B Graff IV
Assignee
The Procter & Gamble Company
OH, US
IPC
A61K 31/60
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