04943522 is referenced by 281 patents and cites 9 patents.

A method and apparatus for conducting specific binding pair assays, such as immunoassays, is described. A porous membrane capable of non-bibulous lateral flow is used as assay substrate; a member of the binding pair is affixed in an indicator zone defined in the substrate. The sample is applied at a position distant from the indicator zone and permitted to flow laterally through the zone; any analyte in the sample is complexed by the affixed specific binding member, and detected. A novel method of detection employs entrapment of observable particle in the complex. Blood is a particularly preferred sample as the red blood cells can be used as the observable particles for detection of the complex.

Title
Lateral flow, non-bibulous membrane assay protocols
Application Number
57271
Publication Number
4943522
Application Date
August 10, 1988
Publication Date
July 24, 1990
Inventor
Robert B Sargeant
Ramona
CA, US
David H Katz
La Jolla
CA, US
Mohammed H Khalil
San Diego
CA, US
Robert W Eisinger
San Diego
CA, US
Agent
Irell & Manella
Assignee
Quidel
CA, US
IPC
G01N 33/53
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